Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition associated with increased morbidity and mortality, particularly during respiratory infections such as influenza. The interaction between COPD and influenza is multifaceted, involving compromised immune responses, chronic inflammation, and impaired lung function. Influenza infection can exacerbate COPD, leading to acute exacerbations, hospitalisations, and higher mortality. This review examines the pathophysiological
mechanisms underlying the exacerbation of COPD by influenza, evaluates its impact on patient outcomes, and explores the role of comorbidities in shaping disease severity. We also assess the effectiveness of influenza vaccination in preventing severe outcomes and discuss strategies to improve vaccination uptake
among COPD patients. Current evidence highlights the importance of tailored prevention and management approaches, as well as the need for further research into biomarkers and optimal therapeutic strategies to mitigate the burden of influenza on COPD populations.
Influenza
Preventing Influenza and Pneumococcal Infections Reduces Adverse Outcomes
Preventing Influenza and Pneumococcal Infections Reduces Adverse Outcomes – MM1702
One of the strategic objectives of the 2011-2020 Global Vaccine Action Plan is for the benefits of immunisation
to be equitably extended to all people and encompasses special groups at increased risk of vaccine-preventable
diseases, such as preterm infants and pregnant women, as well as those with chronic and immune-compromising
medical conditions or at increased risk of disease due to immunosenescence. Despite demonstrations
of effectiveness and safety, vaccine uptake in these special groups is frequently lower than expected, even
in developed countries with vaccination strategies in place. For example, uptake of the influenza vaccine in
pregnancy rarely exceeds 50% in developed countries and, although data are scarce, it appears that only half
of preterm infants are up-to-date with routine paediatric vaccinations.
Modern Medicine – February 2017
Influenza Time to Vaccinate But Who and Why?
Influenza Time to Vaccinate But Who and Why? – MM1503
Influenza vaccination should be recommended not only to all patients who qualify for the government-funded vaccine but also to those shown to be at increased risk of complications in the 2009-10 influenza pandemic, including the clinically obese and tobacco smokers.
Modern Medicine – March 2015
