Dopamine and Noradrenaline ReuptakeĀ ā MM1504
The mechanism of action of bupropion is still uncertain but may beĀ related to inhibition of presynaptic dopamine and noradrenalineĀ reuptake transporters. The activity of vesicular monoamineĀ transporter-2, the transporter pumping dopamine, noradrenalineĀ and serotonin from the cytosol into presynaptic vesicles, isĀ increased by bupropion and may be a component of its mechanismĀ of action. Bupropion is approved for use in major depression andĀ seasonal affective disorder and has demonstrated comparableĀ efficacy to other antidepressants in clinical trials.
Modern Medicine ā AprilĀ 2015
