Asthma is a common, multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes and endotypes and the availability of targeted biologic treatment options, the disease remains uncontrolled in many patients with risk of exacerbations, requiring systemic corticosteroids, and with progressive disease. A personalised management approach to patients with uncontrolled severe asthma is advocated. This asthma expert panel was convened to discuss strategies to optimise asthma care and to prevent systemic corticosteroid overuse and disease progression. Current concepts and recommendations are summarised, and a rationale is provided to implement personalised asthma management at earlier stages of the disease. The ultimate goal is to move away from the current one-size-fits-most concept and shift toward a phenotype- and endotypetargeted approach aimed at curbing the disease course by improving outcomes. A consensus view on asthma care is provided that advocates a holistic approach and highlights some unmet needs to be addressed in future clinical trials and population studies. This is a shortened version of the article.
Modern Medicine – Issue 4, 2025
