Major depressive disorder is one of the leading causes of disability, morbidity and mortality worldwide. The disorder affects approximately one in five people at any stage of their lifespan. It is generally agreed upon that depression is induced by the cumulative effect of genetic information and environmental stresses. Certain genes and psychological features might predispose some people to depression and stressful life events including early-life stress are important inducements of depression. Research has indicated that the gut microbiota also play a crucial part in the pathophysiology of depression.
Modern Medicine – Issue 4 2019