Diuretic Resistance, a Factor in Chronic Kidney Disease ā MM1605
Diuretics exert their effects via the kidney, relying onĀ secretion, and to a minor degree on glomerular filtration, toĀ achieve therapeutic concentrations in the tubule. DiabetesĀ and atherosclerosis can both cause glomerular damageĀ and glomerulosclerosis, affecting glomerular filtration rateĀ (GFR), while the Renin-Angiotensin system activation andĀ inflammation common to both conditions also contributes toĀ a reduced response.
Modern Medicine ā MayĀ 2016
