{"id":982,"date":"2015-04-28T13:45:41","date_gmt":"2015-04-28T11:45:41","guid":{"rendered":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=982"},"modified":"2015-04-28T13:45:41","modified_gmt":"2015-04-28T11:45:41","slug":"dopamine-and-noradrenaline-reuptake","status":"publish","type":"post","link":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=982","title":{"rendered":"Dopamine and Noradrenaline Reuptake"},"content":{"rendered":"<p><a title=\"Modern Medicine - April 2015 Edition\" href=\"http:\/\/www.modernmedia.co.za\/modernmedicine\/DigitalEditions\/mm1504-april-2015\/index.html\" target=\"_blank\">Dopamine and Noradrenaline Reuptake\u00a0\u2013 MM1504<\/a><\/p>\n<p>The mechanism of action of bupropion is still uncertain but may be\u00a0related to inhibition of presynaptic dopamine and noradrenaline\u00a0reuptake transporters. The activity of vesicular monoamine\u00a0transporter-2, the transporter pumping dopamine, noradrenaline\u00a0and serotonin from the cytosol into presynaptic vesicles, is\u00a0increased by bupropion and may be a component of its mechanism\u00a0of action. Bupropion is approved for use in major depression and\u00a0seasonal affective disorder and has demonstrated comparable\u00a0efficacy to other antidepressants in clinical trials.<\/p>\n<p><em>Modern Medicine \u2013 April\u00a02015<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dopamine and Noradrenaline Reuptake\u00a0\u2013 MM1504 The mechanism of action of bupropion is still uncertain but may be\u00a0related to inhibition of presynaptic dopamine and noradrenaline\u00a0reuptake transporters. The&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2},"beyondwords_generate_audio":"","beyondwords_project_id":"","beyondwords_content_id":"","beyondwords_preview_token":"","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"categories":[142],"tags":[],"class_list":["post-982","post","type-post","status-publish","format-standard","hentry","category-cns"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5REYo-fQ","_links":{"self":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=982"}],"version-history":[{"count":1,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/982\/revisions"}],"predecessor-version":[{"id":983,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/982\/revisions\/983"}],"wp:attachment":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=982"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}