{"id":656,"date":"2014-01-21T09:57:07","date_gmt":"2014-01-21T07:57:07","guid":{"rendered":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=656"},"modified":"2014-01-21T09:57:07","modified_gmt":"2014-01-21T07:57:07","slug":"the-physiology-of-chronic-pain-the-role-of-the-inhibitory-interneuron","status":"publish","type":"post","link":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=656","title":{"rendered":"The Physiology of Chronic Pain The Role of the Inhibitory Interneuron"},"content":{"rendered":"<p><a title=\"Modern Medicine - January 2014\" href=\"http:\/\/www.modernmedia.co.za\/modernmedicine\/DigitalEditions\/mm1401-january-2014\/index.html\" target=\"_blank\">The Physiology of Chronic Pain The Role of the Inhibitory Interneuron\u00a0&#8211; MM1401<\/a><\/p>\n<p>As described in the original article in May 2013, central sensitisation\u00a0of the dorsal horn cells with facilitated pain processing and\u00a0transmission can occur after nerve injury, deafferentation of the\u00a0spinal cord (amputation or nerve section) or due to afferent barrage.<br \/>\nAs a result, anatomical and neuro-chemical changes can occur\u00a0within the central nervous system (CNS) that can persist long after\u00a0the injury has healed.<br \/>\nThis \u2018CNS plasticity\u2019 may play an important role in the evolution of\u00a0chronic, neuropathic pain. The sensitisation of neurons that occurs\u00a0within the dorsal horn results in spontaneous activity of the dorsal\u00a0horn neurons, a decreased threshold and an increased responsivity\u00a0to afferent input, and cell death in the spinal dorsal horn. The cells\u00a0that die are the inhibitory interneurons.<\/p>\n<p><em>Modern Medicine \u2013 January 2014<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Physiology of Chronic Pain The Role of the Inhibitory Interneuron\u00a0&#8211; MM1401 As described in the original article in May 2013, central sensitisation\u00a0of the dorsal horn&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2},"beyondwords_generate_audio":"","beyondwords_project_id":"","beyondwords_content_id":"","beyondwords_preview_token":"","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"categories":[39,11],"tags":[],"class_list":["post-656","post","type-post","status-publish","format-standard","hentry","category-neurology","category-pain"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5REYo-aA","_links":{"self":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=656"}],"version-history":[{"count":1,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/656\/revisions"}],"predecessor-version":[{"id":657,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/656\/revisions\/657"}],"wp:attachment":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=656"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}