{"id":3911,"date":"2026-03-09T11:15:05","date_gmt":"2026-03-09T09:15:05","guid":{"rendered":"https:\/\/www.modernmedia.co.za\/modernmedicine\/?p=3911"},"modified":"2026-03-09T11:15:05","modified_gmt":"2026-03-09T09:15:05","slug":"typical-reflux-disease-recognition-and-management-of-resistance-to-therapy","status":"publish","type":"post","link":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=3911","title":{"rendered":"Typical Reflux Disease | Recognition and management of resistance to therapy"},"content":{"rendered":"\n<p><a href=\"https:\/\/modernmedia.co.za\/modernmedicine\/DigitalEditions\/MM2601-2602-January-February-2026\/index.html?page=25\">Recognition and Management of Resistance to Therapy<\/a><\/p>\n\n\n\n<p>Diagnosis of gastro-oesophageal reflux disease depends on recognising the cardinal symptoms of heartburn and regurgitation, with faulty diagnosis contributing to apparent failures of medical management. Proton pump inhibitors (PPIs) are the mainstay of treatment for most patients with gastro-oesophageal reflux disease, but 20 to 30% of patients remain symptomatic despite therapy. Management of persistent reflux symptoms, including heartburn, regurgitation and chest pain, that are not well controlled by medical therapy may require insightful physiological management. Systematic reviews have<br>found that minimally invasive laparoscopic antireflux surgery is superior to medical management in treating refractory reflux disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recognition and Management of Resistance to Therapy Diagnosis of gastro-oesophageal reflux disease depends on recognising the cardinal symptoms of heartburn and regurgitation, with faulty diagnosis contributing&#46;&#46;&#46;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2},"beyondwords_generate_audio":"","beyondwords_project_id":"","beyondwords_content_id":"","beyondwords_preview_token":"","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"categories":[73],"tags":[],"class_list":["post-3911","post","type-post","status-publish","format-standard","hentry","category-gastroenterology"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5REYo-115","_links":{"self":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/3911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3911"}],"version-history":[{"count":1,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/3911\/revisions"}],"predecessor-version":[{"id":3912,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/3911\/revisions\/3912"}],"wp:attachment":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3911"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}