{"id":3004,"date":"2021-12-01T19:34:45","date_gmt":"2021-12-01T17:34:45","guid":{"rendered":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=3004"},"modified":"2022-01-06T13:02:20","modified_gmt":"2022-01-06T11:02:20","slug":"neuro-modulation-a-new-approach-to-hf","status":"publish","type":"post","link":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=3004","title":{"rendered":"Neuro-modulation: A New Approach to HF"},"content":{"rendered":"\n

Neuro-modulation: A New Approach to HF<\/a><\/p>\n\n\n\n

Heart failure (HF) is a complex clinical syndrome characterised by abnormalities in cardiac structure and function, dynamic remodelling, and perturbations of the neurohormonal axis. recently, the concept of neuro-modulation, rather than neuro-inhibition, has been successfully tested with the angiotensin receptor neprilysin inhibitor (arni) class representing a potential shift in the treatment of HF from partial neurohormonal system inhibition to an integrated composite neurohormonal system modulation.<\/p>\n\n\n\n

Modern Medicine \u2013 Issue 6 2<\/em>021<\/p>\n","protected":false},"excerpt":{"rendered":"

Neuro-modulation: A New Approach to HF Heart failure (HF) is a complex clinical syndrome characterised by abnormalities in cardiac structure and function, dynamic remodelling, and perturbations...<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2},"beyondwords_generate_audio":"","beyondwords_project_id":"1549","beyondwords_content_id":"","beyondwords_preview_token":"","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"3081239","beyondwords_hash":"","publish_post_to_speechkit":"1","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"1549","speechkit_podcast_id":"3081239","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"{\"headers\":{},\"body\":\"{\"id\":\"3004\",\"podcast_id\":3081239,\"url\":\"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=3004\",\"title\":\"Neuro-modulation: A New Approach to HF\",\"author\":\"Peter\",\"summary\":\"\",\"image\":\"f\",\"published_at\":\"2021-12-01T17:34:45.000Z\",\"body\":\"Heart failure (HF) is a complex clinical syndrome characterised by abnormalities in cardiac structure and function, dynamic remodelling, and perturbations of the neurohormonal axis. recently, the concept of neuro-modulation, rather than neuro-inhibition, has been successfully tested with the angiotensin receptor neprilysin inhibitor (arni) class representing a potential shift in the treatment of HF from partial neurohormonal system inhibition to an integrated composite neurohormonal system modulation.\\nModern Medicine u2013 Issue 6 2021\",\"state\":\"processed\",\"share_url\":\"https:\/\/audio.beyondwords.io\/a\/3081239\",\"share_version\":\"v2\",\"media\":[{\"id\":11882358,\"role\":\"body\",\"content_type\":\"application\/x-mpegURL\",\"url\":\"https:\/\/d22tbkdovk5ea2.cloudfront.net\/audio\/projects\/1549\/podcasts\/3081239\/media\/6df6fbceaf4e748051e222fc4ed72529.m3u8\",\"download_url\":null,\"created_at\":\"2021-12-01T17:35:34.691Z\",\"updated_at\":\"2021-12-01T17:35:34.691Z\",\"state\":\"processed\",\"duration\":38,\"voice\":null},{\"id\":11882349,\"role\":\"body\",\"content_type\":\"audio\/mpeg\",\"url\":\"https:\/\/d22tbkdovk5ea2.cloudfront.net\/audio\/projects\/1549\/podcasts\/3081239\/media\/71e37fd9bb713f7cb4e1871c31c49baf_compiled.mp3\",\"download_url\":null,\"created_at\":\"2021-12-01T17:35:21.370Z\",\"updated_at\":\"2021-12-01T17:35:21.370Z\",\"state\":\"processed\",\"duration\":38,\"voice\":null}],\"player_type\":\"MinimalPlayer\",\"next_podcast_external_id\":null,\"ad_disabled\":false,\"project_id\":1549}\",\"response\":{\"code\":200,\"message\":\"OK\"},\"cookies\":[{\"name\":\"__cf_bm\",\"value\":\"wYhZ9p_ZZoHl.LmLnCf2DuPwBdlSLAeviTIewIqjKUg-1641467008-0-AU68PpULXOvNFDudGI Og 8HDpfSYRujnAnJFwxZSEtQJ9trb1Kc8yoVRWlqRg0UzXpWbzDOmSSTdHtL 9l0FlE=\",\"expires\":1641468808,\"path\":\"\/\",\"domain\":\"speechkit.io\",\"host_only\":false}],\"filename\":null,\"http_response\":{\"data\":null,\"headers\":null,\"status\":null}}","speechkit_retries":"0","speechkit_status":"Processed","speechkit_updated_at":"","_speechkit_link":"https:\/\/audio.beyondwords.io\/a\/3081239","_speechkit_text":"436a340e2a040c5df86aff93e683281b"},"categories":[7],"tags":[],"class_list":["post-3004","post","type-post","status-publish","format-standard","hentry","category-cardiology"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5REYo-Ms","_links":{"self":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/3004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3004"}],"version-history":[{"count":2,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/3004\/revisions"}],"predecessor-version":[{"id":3041,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/3004\/revisions\/3041"}],"wp:attachment":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3004"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}