{"id":1927,"date":"2018-09-26T10:28:08","date_gmt":"2018-09-26T08:28:08","guid":{"rendered":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=1927"},"modified":"2018-09-26T10:28:08","modified_gmt":"2018-09-26T08:28:08","slug":"tapentadol-the-only-mor-nri-for-broad-spectrum-pain-relief","status":"publish","type":"post","link":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=1927","title":{"rendered":"Tapentadol, the Only MOR-NRI for Broad Spectrum Pain Relief"},"content":{"rendered":"<p><a href=\"http:\/\/www.modernmedia.co.za\/modernmedicine\/DigitalEditions\/mm1808-09-august-september-2018\/html5\/index.html\">Tapentadol, the Only MOR-NRI for Broad Spectrum Pain Relief<\/a><\/p>\n<p>Tapentadol is the first centrally acting analgesic that combines two mechanisms of action, m\u03bc-opioid receptor agonism and noradrenaline reuptake inhibition (MOR\u2013NRI), in a single molecule.1 The synergistic interactions between the two mechanisms provide inhibition of ascending pain signals through MOR agonism and enhancement of descending pain inhibition through NRI. The result is broad efficacy across nociceptive, neuropathic and mixed pain.<\/p>\n<p><em>Modern Medicine \u2013 Aug\/Sept 2018<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tapentadol, the Only MOR-NRI for Broad Spectrum Pain Relief Tapentadol is the first centrally acting analgesic that combines two mechanisms of action, m\u03bc-opioid receptor agonism and&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2},"beyondwords_generate_audio":"","beyondwords_project_id":"","beyondwords_content_id":"","beyondwords_preview_token":"","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"categories":[11],"tags":[],"class_list":["post-1927","post","type-post","status-publish","format-standard","hentry","category-pain"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5REYo-v5","_links":{"self":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1927"}],"version-history":[{"count":1,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1927\/revisions"}],"predecessor-version":[{"id":1928,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1927\/revisions\/1928"}],"wp:attachment":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1927"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}