{"id":1362,"date":"2016-10-31T21:41:04","date_gmt":"2016-10-31T19:41:04","guid":{"rendered":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=1362"},"modified":"2016-10-31T21:41:04","modified_gmt":"2016-10-31T19:41:04","slug":"using-genetic-information-improves-drug-therapy","status":"publish","type":"post","link":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=1362","title":{"rendered":"Using Genetic Information Improves Drug Therapy"},"content":{"rendered":"<p><a href=\"http:\/\/www.modernmedia.co.za\/modernmedicine\/DigitalEditions\/mm1610-october-2016\/index.html\" target=\"_blank\">Using Genetic Information Improves Drug Therapy \u2013 MM1610<\/a><\/p>\n<p>Clinical pharmacogenomics, the use of genetic data to guide therapy decisions, can help determine whether individual differences in the expression of proteins or enzymes affect the metabolism of a particular drug. These effects can change the levels of active or inactive metabolites, which require the use of a different drug or altered dose for optimum efficacy.<br \/>\nFamily doctors are usually the first resource for patient questions about genetics; but quick and accurate use of pharmacogenomic data in a clinical environment can be challenging. Patients have increasing interest in and access to their own genetic information, including pharmacogenomic data from direct-to-consumer genetic testing companies. Clinicians, however, are largely unfamiliar with principles supporting clinical use of this type of data and few primary care doctors are comfortable ordering a pharmacogenomic test or interpreting test results, often citing a general lack of education in this area.<br \/>\nWhen used appropriately, pharmacogenetic testing can be a practical tool to optimise drug therapy and avoid medication adverse effects.<\/p>\n<p><em>Modern Medicine \u2013 October\u00a02016<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using Genetic Information Improves Drug Therapy \u2013 MM1610 Clinical pharmacogenomics, the use of genetic data to guide therapy decisions, can help determine whether individual differences in&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2},"beyondwords_generate_audio":"","beyondwords_project_id":"","beyondwords_content_id":"","beyondwords_preview_token":"","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"categories":[130,188,189],"tags":[],"class_list":["post-1362","post","type-post","status-publish","format-standard","hentry","category-diagnostics","category-genetics","category-pharmacogenomics"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5REYo-lY","_links":{"self":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1362"}],"version-history":[{"count":1,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1362\/revisions"}],"predecessor-version":[{"id":1363,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1362\/revisions\/1363"}],"wp:attachment":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1362"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}