{"id":1275,"date":"2016-06-30T13:23:49","date_gmt":"2016-06-30T11:23:49","guid":{"rendered":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=1275"},"modified":"2016-06-30T13:23:49","modified_gmt":"2016-06-30T11:23:49","slug":"practical-use-of-the-nonvitamin-k-antagonist-oral-anticoagulants","status":"publish","type":"post","link":"http:\/\/www.modernmedia.co.za\/modernmedicine\/?p=1275","title":{"rendered":"Practical Use of the Nonvitamin K Antagonist Oral Anticoagulants"},"content":{"rendered":"<p><a href=\"http:\/\/www.modernmedia.co.za\/modernmedicine\/DigitalEditions\/mm1606-june-2016\/index.html\" target=\"_blank\">Practical Use of the Nonvitamin K Antagonist Oral Anticoagulants \u2013 MM1606<\/a><\/p>\n<p>NOACs (nonvitamin K antagonist oral anticoagulants) are\u00a0an alternative to vitamin K antagonists such as warfarin\u00a0for: prevention of stroke in patients with nonvalvular atrial\u00a0fibrillation and of venous thromboembolism in adults after\u00a0elective total hip or knee replacement; treatment of deep\u00a0vein thrombosis (DVT) and pulmonary embolism (PE) as\u00a0well as prevention of recurrent DVT and PE.<br \/>\nThe NOACs dabigatran and rivaroxaban differ in\u00a0their properties, including mode of action and drug\u00a0interactions; these differences must be taken into account\u00a0when assessing patient suitability for NOAC therapy.\u00a0Laboratory monitoring required for NOACs differs\u00a0significantly from that used for warfarin. Perioperative\u00a0use of NOACs is common but management differs\u00a0between drugs, depending on their pharmacokinetic and\u00a0pharmacodynamic properties.<\/p>\n<p><em>Modern Medicine \u2013 June\u00a02016<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Practical Use of the Nonvitamin K Antagonist Oral Anticoagulants \u2013 MM1606 NOACs (nonvitamin K antagonist oral anticoagulants) are\u00a0an alternative to vitamin K antagonists such as warfarin\u00a0for:&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2},"beyondwords_generate_audio":"","beyondwords_project_id":"","beyondwords_content_id":"","beyondwords_preview_token":"","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"categories":[177],"tags":[],"class_list":["post-1275","post","type-post","status-publish","format-standard","hentry","category-anticoagulants"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5REYo-kz","_links":{"self":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1275"}],"version-history":[{"count":1,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1275\/revisions"}],"predecessor-version":[{"id":1276,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=\/wp\/v2\/posts\/1275\/revisions\/1276"}],"wp:attachment":[{"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1275"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.modernmedia.co.za\/modernmedicine\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}